A combination of two new therapies already in clinical trials for the treatment of primary malignant brain tumors may also be effective in the treatment of breast cancer that has spread to the brain, according to US researchers.
The researchers demonstrated their new approach, which combines immunotherapy with gene therapy, in mice. The vast majority of deaths from cancer are because of metastasis, where the cancer spreads from the primary site to other parts of the body, such as the brain. Patients with metastatic brain tumors have a very poor prognosis since most current treatments rely on chemotherapy, and many of the drugs are ineffective because the brain is protected by the blood-brain barrier.
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